diff --git a/lib/datadog/profiling/component.rb b/lib/datadog/profiling/component.rb
index 0d31084f745..961b2e7ad97 100644
--- a/lib/datadog/profiling/component.rb
+++ b/lib/datadog/profiling/component.rb
@@ -220,6 +220,12 @@ def self.build_profiler_component(settings:, agent_settings:, optional_tracer:,
             "Please upgrade to Ruby >= 3.1 in order to use this feature. Heap profiling has been disabled."
           )
           return false
+        elsif RUBY_VERSION.start_with?("4.")
+          logger.warn(
+            "Heap profiling is not supported in current Ruby version (#{RUBY_VERSION}) due to https://bugs.ruby-lang.org/issues/21710. " \
+            "Heap profiling has been disabled."
+          )
+          return false
         end
 
         unless allocation_profiling_enabled
diff --git a/spec/datadog/profiling/collectors/cpu_and_wall_time_worker_spec.rb b/spec/datadog/profiling/collectors/cpu_and_wall_time_worker_spec.rb
index 408abf1ddd8..0d411db45ec 100644
--- a/spec/datadog/profiling/collectors/cpu_and_wall_time_worker_spec.rb
+++ b/spec/datadog/profiling/collectors/cpu_and_wall_time_worker_spec.rb
@@ -868,6 +868,7 @@
 
       before do
         skip "Heap profiling is only supported on Ruby >= 2.7" if RUBY_VERSION < "2.7"
+        skip "Heap profiling is disabled on Ruby 4 until https://bugs.ruby-lang.org/issues/21710 is fixed" if RUBY_VERSION.start_with?("4.")
         allow(Datadog.logger).to receive(:warn)
         expect(Datadog.logger).to receive(:warn).with(/dynamic sampling rate disabled/)
       end
diff --git a/spec/datadog/profiling/component_spec.rb b/spec/datadog/profiling/component_spec.rb
index 15d97b7d7c5..fdee2850a33 100644
--- a/spec/datadog/profiling/component_spec.rb
+++ b/spec/datadog/profiling/component_spec.rb
@@ -334,6 +334,20 @@
             end
           end
 
+          context "on Ruby 4.0 or newer" do
+            let(:testing_version) { "4.0.0" }
+
+            it "initializes StackRecorder without heap sampling support and warns" do
+              expect(Datadog::Profiling::StackRecorder).to receive(:new)
+                .with(hash_including(heap_samples_enabled: false, heap_size_enabled: false))
+                .and_call_original
+
+              expect(logger).to receive(:warn).with(/Heap profiling is not supported.*21710/)
+
+              build_profiler_component
+            end
+          end
+
           context "and allocation profiling disabled" do
             before do
               settings.profiling.allocation_enabled = false